The potential of visual physiology: An instrument with a place in MS translation

摘要

Whilst there may be a strong biological rationale for pursuing RMTs, several important considerations remain. Firstly, it is hoped that the more prolonged testing time for mfVEPs is not too hin- dered by the ubiquitous fatigue afflicting MS patients, which can limit even shorter standard VEP acquisition. Secondly, there remains concern surrounding the criterion validity of visual phys- iology to act as a surrogate of overall clinical disability in MS. Bar- ton and colleagues recognise that the relationship between visual electrophysiology and clinical disability outcomes used in phase 3 trials is likely to be poor.