Background: The purpose of this study was to determine visual acuity at different contrast levels under photopic and mesopic conditions in patients with retinitis pigmentosa.Methods: Sixty eyes of 31 normal controls, 92 eyes of 52 patients with retinitis pigmentosa without other ocular disorders (RP-1 group), and 20 eyes of 14 patients with retinitis pigmentosa with cataracts and without other ocular disorders (RP-2 group) were studied. Conventional visual acuity was measured using a conventional Landolt ring chart with 100% contrast and luminance of 150 cd/m2. All of the patients with retinitis pigmentosa had a decimal visual acuity better than 1.0. Contrast visual acuity was measured with the same Landolt ring chart with contrasts of 100% and 10% and under photopic (200 cd/m2) and mesopic (10 cd/m2) conditions. Decimal visual acuities were converted to logMAR units for the analyses.Results: The 100% contrast visual acuity and the 10% contrast visual acuity determined under both photopic and mesopic conditions were significantly poorer in both the RP-1 and RP-2 groups than in the controls. The differences between the conventional visual acuity and the 100% contrast visual acuity were significantly greater in the RP-1 and RP-2 groups than in the controls under both photopic and mesopic conditions. The differences between the 100% contrast visual acuity and the 10% contrast visual acuity were not significant among the three groups under photopic and mesopic conditions.Conclusion: Contrast visual acuities were greatly reduced in patients with retinitis pigmentosa with relatively well preserved conventional visual acuity, and the contrast visual acuity was largely influenced by ambient light levels in patients with retinitis pigmentosa. Although a longitudinal study for confirmation has to be performed, our findings indicate that contrast visual acuity is a better test to follow changes in visual function in patients with retinitis pigmentosa.
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机译：背景：本研究的目的是确定色素性视网膜炎患者在明视和中视条件下在不同对比度水平下的视力。方法：31名正常对照者60眼，52例无其他眼部疾病的视网膜色素变性患者（RP） -1组）和14例患有白内障且无其他眼部疾病的色素性视网膜色素变性患者（RP-2组）的20眼进行了研究。使用常规的Landolt环形图测量常规视力，对比度为100％，亮度为150 cd / m2。所有色素性视网膜炎患者的十进制视力均优于1.0。使用相同的Landolt环图在100％和10％的对比度下以及在明视（200 cd / m2）和中观（10 cd / m2）条件下测量对比视力。将小数视力转换为logMAR单位进行分析。结果：在RP-1和RP-2组中，在明视和中视条件下测定的100％对比视敏度和10％对比视敏度均显着低于RP-1和RP-2组。控件。在明视和中视条件下，RP-1和RP-2组的常规视敏度和100％对比视敏度之间的差异均显着大于对照组。三组在明视和中视条件下，100％对比视力和10％对比视力之间的差异不显着。结论：保留相对良好常规眼力的色素性视网膜炎患者的对比视力大大降低，色素性视网膜炎患者的对比视敏度在很大程度上受环境光水平的影响。尽管必须进行纵向研究以进行确认，但我们的发现表明，对比色视力是追踪色素性视网膜炎患者视觉功能变化的更好方法。
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