Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children

摘要

Purpose: Myopia in school-age children has become increasingly prevalent in industrialized countries, especially in Asia. A large population of school-age children still suffers from low visual acuity. We have developed a novel, safe and noninvasive training method to activate a pupillary constriction response during far accommodation that results in improved visual acuity.Methods: Myopic children (n = 95) were treated for 3-minute sessions up to twice a week for 12–106 weeks. We stimulated quick cycles of near/far accommodation by displaying a visual object on a LCD screen and moving the screen in cycles from a near (25 cm) to a far (70 cm) point and back, while keeping the retinal projection size and brightness of the object constant. Results: Mechanistically, we noted pupillary constriction upon far accommodation in trained myopic children, which was not seen in normal subjects or in untrained myopic children. Eighty five percent (52/61) of trained myopic right eyes with two sessions weekly experienced improved visual acuity (VA) by more than 0.1 logMAR units with an average improvement of 0.30 ± 0.03 standard error of mean (SEM) logMAR units. With maintained training, most eyes’ improved VA stayed almost constant, for more than 50 weeks in the case of 12 long trained subjects.Conclusions: This simple, short and safe accommodation training greatly improves the quality of vision in a large population suffering from refractive abnormalities.