Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

摘要

BackgroundEpigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone acetyltransferases (KATs) in AAA. ResultsA comparative study of AAA tissue samples ( n =?37, open surgical intervention) and healthy aortae ( n =?12, trauma surgery) was performed using quantitative PCR, immunohistochemistry (IHC), and Western blot. Expression of the KAT families GNAT (KAT2A, KAT2B), p300/CBP (KAT3A, KAT3B), and MYST (KAT5, KAT6A, KAT6B, KAT7, KAT8) was significantly higher in AAA than in controls ( P ≤?0.019). Highest expression was observed for KAT2B, KAT3A, KAT3B, and KAT6B ( P ≤?0.007). Expression of KAT2B significantly correlated with KAT3A, KAT3B, and KAT6B ( r =?0.705, 0.564, and 0.528, respectively, P ConclusionsOur results demonstrate that aberrant epigenetic modifications such as changes in the expression of KATs and acetylation of corresponding histones?are present in AAA. These findings may provide new insight in the pathomechanism of AAA.