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首页> 外文期刊>Clinical and vaccine immunology: CVI >Spiramycin Treatment of Toxoplasma gondii Infection in Pregnant Women Impairs the Production and the Avidity Maturation of T. gondii-Specific Immunoglobulin G Antibodies
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Spiramycin Treatment of Toxoplasma gondii Infection in Pregnant Women Impairs the Production and the Avidity Maturation of T. gondii-Specific Immunoglobulin G Antibodies

机译:螺旋霉素治疗孕妇弓形虫感染会损害弓形虫特异性免疫球蛋白G抗体的生产和亲和力成熟。

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The aim of the study was to evaluate the influence of treatment with spiramycin on the increase of immunoglobulin G (IgG) titers and IgG avidity indexes (AI) in pregnant women with seroconversion from the beginning of therapy until delivery and after delivery. This group was compared with adult patients with recently acquired untreated toxoplasmosis. One hundred four samples from 32 pregnant women with seroconversion for toxoplasmosis and/or very low IgG AI were followed from the beginning of therapy with spiramycin until delivery. Twenty-nine women were further followed some months after delivery and interruption of therapy. Thirty-eight samples from 16 untreated, nonpregnant patients were evaluated as the control group. The Toxoplasma gondii-specific IgG antibody and the T. gondii-specific IgG AI were significantly delayed in pregnant women receiving therapy compared to nonpregnant, untreated controls, and the findings were consistent with the results of assays from two different manufacturers. The T. gondii-specific IgG AI increased in pregnant women after they gave birth. Avidity maturation is delayed during pregnancy and treatment, and low-avidity antibodies in pregnant women within 3 to 4 months cannot be taken as a sign of infection.
机译:这项研究的目的是评估从治疗开始到分娩和分娩后血清转换的孕妇使用螺旋霉素治疗对免疫球蛋白G(IgG)滴度和IgG亲和力指数(AI)升高的影响。将这一组与最近获得未经治疗的弓形虫病的成人患者进行比较。从开始使用螺旋霉素直至分娩开始,从32例针对弓形虫病和/或IgG极低的血清型转变的孕妇中采集了140个样本。分娩和中断治疗后几个月,对29名妇女进行了进一步随访。将来自16名未接受治疗,未怀孕患者的38份样品评估为对照组。 弓形虫特异性IgG抗体和 T。与未怀孕,未经治疗的对照组相比,接受治疗的孕妇的冈地特异IgG AI显着延迟,该发现与两家不同制造商的检测结果一致。 T。孕妇分娩后刚体特异性IgG AI增加。亲和力成熟在怀孕和治疗期间会延迟,并且孕妇在3到4个月内的低抗体抗体不能被视为感染的迹象。

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