Anti-Mutated Citrullinated Vimentin antibodies (Anti-MCV): A Relation with Other Diagnostic Markers in Rheumatoid Arthritis Patients

摘要

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by autoantibodies against citrullinated antigens. Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis, anti-mutated citrullinated vimentin (Anti-MCV) is another anti-citrullinated antibody reacting with mutated citrullinated vimentin. There are many studies in comparing anti-MCV and ACCP antibodies for their diagnostic value in rheumatoid arthritis. Anti-MCV especially correlates with higher levels of DAS28 core and joint damage. The aim of this study was to determine the sensitivity and specificity of anti-MCV antibodies in comparison with other inflammatory markers and disease activity in Egyptian rheumatoid arthritis patients. Patients and Methods: Fifty female rheumatoid arthritis patients, were allocated from Rheumatology outpatient clinic and inpatients Internal Medicine Department, Al-Zahraa University Hospital. Their ages ranged from 18 to 74 years with a mean ± SD was (44.6±12.5) years, and fifty healthy volunteers served as a control group. Rheumatoid factor (RF) was measured by latex agglutination, high Sensitive C- Reactive Protein (hs-CRP), Anti-Cyclic Citrullinated Peptides (ACCP) and Anti-Mutated Citrullinated Vimentin (AMCV) were estimated by ELISA. Results: There was statistically highly significant increase in AMCV level with mean ± SD (61.8±47.1 ng/ml) in the patients compared to the control group (8.3±2.9 ng/ml). There was a highly statistically significant correlation between anti-MCV and anti-CCP in the patients (P= 0.001). Also, there was a highly statistically significant correlation between anti-MCV and DAS28 (P= 0.009). The sensitivity of anti-MCV was 92% with 92% specificity, positive predictive value 92%, and negative predictive value 92%. The sensitivity of anti-CCP was 84% with 100% specificity, positive predictive value 100%, and negative predictive value 86.2%. Conclusion: There was a highly significant correlation between anti-MCV and anti-CCP of patients, also highly significant correlation between anti-MCV and DAS28 score. Anti-MCV being more sensitive than anti-CCP while anti-CCP is more specific.