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The development of precision medicine in clinical practice

机译:精准医学在临床实践中的发展

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Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an increasing wealth of data unanalyzed. The concept of precision medicine is about the customization of healthcare, with decisions and practices tailored to an individual patient based on their intrinsic biology in addition to clinical “signs and symptoms”. Construction of a standardized model for the integration of data from various platforms is the central mission of the ‘New Disease Management Model’. The model is helpful for the development of new taxonomy of diseases and subtypes, to personalize therapy based on patient genetic profiles. A rapid progression of precision therapy has been made recently. Clinical trials have shown the therapeutic efficacy of discovered and developed therapeutic agents has improved. However, next-generation drugs would be designed for disease subtypes with more specificity, efficacy and lower toxicity.
机译:精密医学极大地扩展了生物学数据,同时仍然迫切需要了解和洞察这些数据对人类健康和疾病的确切含义。这导致越来越多的未经分析的数据。精准医学的概念是关于医疗保健的定制化,除临床“体征和症状”外,还根据患者的内在生物学为他们量身定制决策和实践。构建用于整合来自各种平台的数据的标准化模型是“新疾病管理模型”的中心任务。该模型有助于疾病和亚型的新分类学的发展,有助于根据患者的遗传特征进行个性化治疗。最近,精确疗法迅速发展。临床试验表明,已发现和开发的治疗剂的治疗功效得到了改善。但是,下一代药物将被设计用于具有更高特异性,功效和更低毒性的疾病亚型。

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