Screening of Ameloblastoma Cases in Ibadan for HPV and EBV Genes

摘要

This study investigated the presence or absence of Epstein-Barr virus and Human papilloma virus genes in ameloblastoma, in order to elucidate the genetic origin of this tumour. Methods and Material: 89 archived formalin-fixed paraffin-embedded specimens of ameloblastoma from the year 2000-2010 were genotyped by polymerase chain reaction for Epstein-Barr virus and Human papilloma virus genes Results: None of the 89 ameloblastoma cases used for this study tested positive for Epstein-Barr virus and Human papilloma virus genes. Conclusions: This study suggested that Epstein-Barr virus and Human papilloma virus genes may likely not be involved in the aetiopathogenesis of ameloblastoma in Ibadan environment. Key Messages: Studies have suggested that HPV might be implicated in the pathogenesis of ameloblastoma. In this study none of the extracted DNA samples from the 89 ameloblastoma cases amplified for HPV primer in the PCR, as this may possibly clear the role of this virus in the etiopathogenesis of ameloblastoma or may indicate need for other primers. Further investigation should be done to clarify EBV role in ameloblastoma.