Usefulness of Cystatin C in the Postoperative Management of Pediatric Patients With Congenital Heart Disease

摘要

Background: ?The characteristics of the renal marker cystatin C (Cys-C) in association with the postoperative management of children with congenital heart disease (CHD) remain unclear. Methods and Results: ?Serum Cys-C and creatinine (Cr) levels were measured preoperatively and on the third postoperative day in 53 consecutive CHD patients (age, 1 day–11 years). On the third postoperative day, the patients were divided into 2 groups: the clinically severe group, requiring continuous infusion of diuretic drugs or peritoneal dialysis; and the non-severe group, composed of those without such needs. Preoperative Cys-C level decreased with age (by month) during the first year of life and remained almost constant thereafter, while Cr level increased with age. The Cys-C ratio (Cys-C level on the third postoperative day/preoperative level) was positively correlated with Cr ratio (R=0.57, P