Neuro-imaging techniques are used to extract and assess brain enactments. As brain activations are free to advance in an eccentric way, data driven methods are exploited for functional localization. Three motor imbalance subjects whose scan size were 128 × 128 × 23 and an aggregate of 110 volumes joined by three scans for nine acquisitions, who are on a normal age of 65 years and a set of 10 subject’s simulated data was subjected to examination. To fully exploit the potential, advanced signal processing methods are applied on acquired resting state functional MRI (rsfMRI) and SimTB simulated rsfMRI. An algorithm called Independent Component Analysis-Particle Swam Optimization two-class classifier for decision support is implemented. The algorithm pre-process each simulated and real time rsfMRI scans, extract independent components(IC) from smoothed output, select eigen vector for optimized minimum misclassification from both time series data and perform 2-class classification using k-means clustering. The proposed algorithm aided the classification of about 87.5% of the functional localization of shaky hand subjects of acquired rsfMRI data. The number of highly activated voxels in the sensory motor network is more in shaky hand subjects.
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