Synthesis, Characterization and Anti-hyperglycemic Activity of some novel Formazans Derivatives

摘要

In the present investigation, a series of novel formazans 4[ a – h] were synthesized by the condensation of Schiff bases 2[a-c] and diazonium salt chloride of various substituted aromatic amines 3[a-c] . The intermediate Schiff bases ( 2a-2h) were itself synthesized by the condensation of different aromatic amines 2 ( thiocarbohydrazide , nicotinic hydrazide , carbohydrazide) with various aromatic aldehydes 1 .The completion of reactions was checked by TLC.The structures of the formazan compoundswere identified by FT- IR , 1 H-NMR , 13 C- NMR and mass spectral studies. Newly synthesized compound was screened for their anti- hyperglycemiaactivity .