APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease

摘要

Dysfunctional lipid metabolism plays a central role in pathogenesis of major chronic diseases, and genetic factors are important determinants of individual lipid profiles. We analyzed the associations of two well-established functional polymorphisms (FABP2A54T andAPOEisoforms) with past and family histories of 1492 population samples.FABP2-T54allele was associated with an increased risk of past history of myocardial infarction (odds ratio (OR) = 1.51). Likewise, the subjects withAPOE4, compared withE2andE3, had a significantly increased risk of past history myocardial infarction (OR = 1.89). The OR associated withAPOE4was specifically increased in women for past history of myocardial infarction but decreased for gallstone disease. Interactions between gender andAPOEisoforms were also significant or marginally significant for these two conditions.FABP2-T54allele may be a potential genetic marker for myocardial infarction, andAPOE4may exert sex-dependent effects on myocardial infarction and gallbladder disease.