Efficacy and safety of rt-PA intravenous thrombolysis in the treatment of acute ischemic stroke with hyperdense middle cerebral artery sign: a systematic review

摘要

Objective To systematically review the efficacy and safety of recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolysis in the treatment of acute ischemic stroke with hyperdense middle cerebral artery sign (HMCAS) on CT images. Methods Search online databases such as PubMed, EMBASE/SCOPUS, Cochrane Central Register of Controlled Trials (CENTRAL) and China Biology Medicine (CBM) from January 1994 to December 2014 with