Kinetics of Carvedilol Oxidation by Peroxodisulfate

摘要

The oxidation of indolic beta blocker Carvedilol in the presence of Potassium Perxodisulfate (PDS) in 40% methanol-water has been studied using spectrophotometric method. It has been found that, oxidation reaction starts with electrophilic attack of PDS species on the protonated form of Carvedilol moiety leading to form indolineninic species which become rearranged into more stable indoxyle form. Once it is formed, a second attack of PDS occurs leading to form the final product. The reaction product was characterized as carbazole 1,4 quinone. A polar mechanism was proposed for the oxidation reaction. The detailed mechanism of the reaction was proposed, and thermodynamic parameters were obtained for two steps reaction.