Polycyclic N-Heterocyclic Compounds. Part 63: Improved Synthesis of 5-Amino-1,2-dihydrofuro[2,3-c]isoquinolines via Truce–Smiles Rearrangement and Subsequent Formation to Furo[2,3-c]isoquinoline

摘要

An improved synthesis of 5-amino-1,2-dihydrofuro[2,3- c ]isoquinoline has been achieved using a slight modification of reaction conditions for the Truce–Smiles rearrangement. Acid treatment of the obtained 5-amino-1,2-dihydrofuro[2,3- c ]isoquinolines gave unexpected ring-opened spiro ring compounds. The previously unreported parent compound, furo[2,3- c ]isoquinoline, was also synthesized.