Polycyclic N-Heterocyclic Compounds. Part 63' Improved Synthesis of5-Amino-1,2-dihydrofuro[2,3-c]isoquinolines via Truce–SmilesRearrangement and Subsequent Formation to Furo[2,3-c]isoquinoline

摘要

An improved synthesis of 5-amino-1,2-dihydrofuro[2,3-clisoquinoline has been achieved using a slight modi-fication of reaction conditions for the Truce–Smiles rearrangement. Acid treatment of the obtained 5-amino-1,2-dihydrofuro[2,3-clisoquinolines gave unexpected ring-opened Spiro ring compounds. The previously unreportedparent compound, furo[2,3-clisoquinoline, was also synthesized.