• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Central European Journal of Biology >Insulin resistance is a risk factor for mild cognitive impairment in elderly adults with T2DM
【24h】

Insulin resistance is a risk factor for mild cognitive impairment in elderly adults with T2DM

机译：胰岛素抵抗是老年2型糖尿病患者轻度认知障碍的危险因素

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective The aim of this study was to investigate the clinical effects of insulin resistance (IR) in the development of mild cognitive impairment (MCI) in elderly adults with Type 2 diabetes mellitus (T2DM). Methods Seventy-eight patients with T2DM were recruited and divided into MCI group (26, n=48) and normal group (≥26, n=30) according to the Montreal Cognitive Assessment (MoCA) score. The fasting plasma glucose (FPG), HbA1c, and fasting plasma C-peptide (FPC) were examined and compared between the two groups. The Pancreatic islets function (HOMA-islet) and Insulin Resistance Index (HOMA-IR) were also calculated for the two groups. Using the HOMA-IR and HOMA-islet as the reference, the predicted values for MCI in T2DM patients were calculated by sensitivity, specificity and area under the receiver operating characteristic (ROC) curve. Results The MoCA scores were statistically different between the MCI and control groups (23.79±1.15 vs 28.50±1.01, p0.05). The serum FPG and FPC were 10.38±2.36 mmol/L and 0.79±0.34 ng/mL in the MCI group which were significant different from those of the control group (8.96±2.55 mmol/L and 1.04±0.38 ng/mL; p0.05). The HOMA-IR and HOMA-islet were 10.08±2.64 and 94.67±29.12 for the MCI group and 8.16±2.46 and 130.30±38.43 for the control group; both were statistically different (p0.05). The serum HbA1c was 11.02±2.59% and 9.37±2.00% for the MCI and control groups (significantly different with p0.5). A significant positive correlation was found between MoCA score and HOMA-islet (rpearson=0.44; p0.001). A significant negative correlation existed between MoCA score and serum HbA1c (r=-0.25; p=0.03). The areas under the ROC curve were 0.70 (0.57~0.82), 0.69 (0.57~0.81), 0.69 (0.57~0.80), 0.72 (0.60~0.84), 0.72 (0.60~0.84) and 0.76 (0.65~0.88) respectively for FPG, FPC, HbA1c, HOMA-IR and HOMA-islet. Conclusion Insulin resistance is a risk factor for mild cognitive impairment and can be a biomarker for prediction of MCI in patients with T2DM.
机译：目的本研究的目的是探讨胰岛素抵抗（IR）在2型糖尿病（T2DM）老年人中发展为轻度认知障碍（MCI）的临床效果。方法根据蒙特利尔认知评估（MoCA）评分，招募了78例T2DM患者，分为MCI组（<26，n = 48）和正常组（≥26，n = 30）。在两组之间检查并比较了空腹血浆葡萄糖（FPG），HbA1c和空腹血浆C肽（FPC）。还计算了两组的胰岛功能（HOMA-islet）和胰岛素抵抗指数（HOMA-IR）。使用HOMA-IR和HOMA-islet作为参考，通过敏感性，特异性和受体工作特征（ROC）曲线下的面积来计算T2DM患者的MCI预测值。结果MCI组和对照组之间的MoCA评分有统计学差异（23.79±1.15 vs 28.50±1.01，p <0.05）。 MCI组血清FPG和FPC分别为10.38±2.36 mmol / L和0.79±0.34 ng / mL，与对照组相比有明显差异（8.96±2.55 mmol / L和1.04±0.38 ng / mL; p < 0.05）。 MCI组的HOMA-IR和HOMA-胰岛分别为10.08±2.64和94.67±29.12，对照组为8.16±2.46和130.30±38.43。两者均有统计学差异（p <0.05）。 MCI组和对照组的血清HbA1c分别为11.02±2.59％和9.37±2.00％（p <0.5有显着差异）。在MoCA评分和HOMA胰岛之间发现显着正相关（rpearson = 0.44; p <0.001）。 MoCA评分与血清HbA1c之间存在显着的负相关（r = -0.25; p = 0.03）。 ROC曲线下的面积分别为0.70（0.57〜0.82），0.69（0.57〜0.81），0.69（0.57〜0.80），0.72（0.60〜0.84），0.72（0.60〜0.84）和0.76（0.65〜0.88）。 FPG，FPC，HbA1c，HOMA-IR和HOMA-islet。结论胰岛素抵抗是轻度认知障碍的危险因素，可以作为预测T2DM患者MCI的生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号