EVALUATION OF GASTRIC EMPTYING AND REGIONAL FOOD DISTRIBUTION IN FUNCTIONAL DYSPEPSIA. Fonksiyonel dispepsili hastalarda mide bo?alma zaman? ve b?lgesel da??l?m?n de?erlendirilmesi.

摘要

Functional dyspepsia is a syndrome characterized by symptoms such as epigastric pain, discomfort, early satiety, postprandial fullness and nausea that originate from the gastroduodenal region. The aim of our study is to evaluate the gastric emptying and regional distribution of food in patients with functional dyspepsia.Materials and Method; Seventeen patients with functional dyspepsia (F/M 10/7) and 12 healthy volunteers (F/M 6/6) were enrolled into the study. Following an 8-hour fast, one minute scintigraphic images were obtained in the anterior and posterior projection immediately, 30, 60, 90 and 120 min after a 500mCi (18MBq) Tc99m sulphur colloid-labeled egg, 2 slices of bread and 150 mL of orange juice ingestion. The per cent of radioactivity was calculated by dividing the gastric counts at each time period for total, proximal and distal stomach by the total counts at time zero. The gastric half emptying time (T1/2) was calculated from time activity curves.Results; Total gastric retention at initial and 30 min was not significantly different between patients with FD and controls, whereas a significant difference was observed in the total gastric emptying at 60, 90 and 120 minutes between groups. Although proximal gastric retention was higher in patients with FD compared with the normal subjects at initial, subsequently the ratio of the radioactivity in proximal stomach of FD patients decreased to a level significantly lower than that of controls after 60min. Distal gastric retention was not significantly different at initial and 60 and 90 min between groups or even lower in FD patients compared to the normal subjects, whereas the values at 30 and 120 min. were even lower in the patients than that of controls.In conclusion, impaired gastric accommodation or early proximal emptying may be associated with symptoms in patients with functional dyspepsia. But early antral filling does not seem to be related to the symptoms. ?ZETFonksiyonel dispepsi; orijini üst gastrointestinal sistem olan, abdominal a?r?, huzursuzluk, erken doyma, postprandial doygunluk ve bulant? ile seyreden bir sendromdur. ?al??mam?z?n amac? fonksiyonel dispepsili hastalarda, mide bo?alma zaman? ve b?lgesel da??l?m? de?erlendirmektir.Materyal ve Metod: ?al??mam?za fonksiyonel dispepsi tan?s? alan 17 hasta (E/K: 7/10) ve sa?l?kl? 12 (E/K:6/6) g?nüllü dahil edildi. Hastalar 8 saat a?l?ktan sonra, 500 mCi (18 MBq) Tc99m sülfür kolloid ile i?aretli yumurta 2 dilim ekmek ve 150 ml portakal suyu ile yedikten hemen sonra, her biri 1 dakika olacak ?ekilde 0, 30, 60, 90 ve 120 inci dakikalarda anterior ve posterior projeksiyonlardan say?mlar al?nd?. Her bir zaman?n Total, Proksimal ve Distal gastrik say?mlar? s?f?r an?ndaki say?ma oranlanarak yüzdeleri hesapland?. Zaman aktivite e?risi kullan?larak mide bo?alma zaman? (T1/2) hesap edildi.Bulgular: Total GR de?erleri, 0. ve 30. dakikalardaki normal bireylerden anlaml? farkl?l?k g?stermemesine kar??n, 60. 90. ve 120. dakikalarda normal bireylerden anlaml? azalma g?stermi?tir. Proksimal GR, 0 dakikada hasta grubunda kontrol grubuna oranla anlaml? yüksek bulunmas?na ra?men di?er zamanlarda dü?ük bulundu. 30. dakikadaki azalma anlaml? olmamas?na ra?men di?er zamanlardaki azalma istatistiksel olarak anlaml? idi. Hasta grubunda kontrole g?re ba?lang?? ve 60-90. dakikalarda distal mide retansiyonu anlaml? olarak farkl? de?ilken, 30. ve 120. dakikalardaki de?erler anlaml? dü?ük bulundu.Sonu?: Bozulmu? gastrik uyum veya erken proksimal bo?alma dispepsi ile ili?kili fakat erken antral dolma fonksiyonel dispepsi ile ili?kisizdir.