PRIMA-1METInhibits Growth of Mouse Tumors Carrying Mutant p53

摘要

Reactivation of the tumor suppressor activity to mutant p53 should trigger massive apoptosis and eliminate tumors. The low molecular weight compounds PRIMA-1 and the structural analog PRIMA-1METreactivate human mutant p53in vitroand suppress growth of human tumor xenografts in SCID mice. However, little is known about their effect on mouse mutant p53 in mouse tumor cells. We have examined the effect of PRIMA-1METon mouse sarcomas, mammary carcinomas and chemically induced fibrosarcomas. PRIMA-1METshowed potent growth suppression in mutant p53-carrying mouse tumorsin vitroand a significant anti-tumor effect in syngeneic micein vivo. These results demonstrate that PRIMA-1METtargets mouse tumors carrying mutant p53 and provide strong support for the anti-tumor efficiency of PRIMA-1METin vivo.