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首页> 外文期刊>Cardiology research and practice >Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition
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Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition

机译:碘克沙醇对冠状动脉造影期间呼吸功能的影响以及身体成分的作用

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Purpose. The purposes of this study are to assess the acute effects of iodixanol, an iso-osmolar contrast media, on pulmonary functions and to evaluate the body composition in order to find out its role in causing this deterioration. Methods. 35 male and 25 female patients undergoing diagnostic coronary angiography (CA) were enrolled in the study. Before CA, all patients’ body compositions were evaluated by measuring their body mass indexes (BMIs) and waist-to-hip ratios (WHRs). Total body waters (TBWs), fat masses (FMs), fat-free masses (FFMs), and basal metabolism rates (BMRs) were measured via bioimpedance analysis. The CA was performed via radial artery route using iodixanol in every patient. The pulmonary function tests of these patients were performed before, during, and 2 hours after the CA. FEV1?, FEF25–75%?, and FVC? parameters were calculated by subtracting the measured baseline value from the measurement after the CA. Results. Angiography caused significant reduction in forced expiratory volume in 1?sec (FEV1, from 94.17?±?18.83 to 84.45?±?18.31, ), forced vital capacity (FVC, from 96.57?±?15.82 to 88.31?±?17.96, ), and forced expiratory flow at 25–75% (FEF25–75% from 82.54?±?24.26 to 72.11?±?25.41, ) and remained lower after 2?h after CA in male patients, respectively. FEV1 values were 103.40?±?17.79 to 94.96?±?17.063 (); FVC values were 107.20?±?19.03 to 99.08?±?20.56 (); and FEF25–75% values were 83.92?±?24.30 to 73.24?±?20.45 () before and after CA and remained lower after 2?h after CA in female patients, respectively. FEV1/FVC ratio remained unchanged. FEF25–75%? was statistically correlated with FFM, TBW, and WHR (;,, and , resp.), and FVC? was correlated with WHR in male patients (,). Conclusions. Our data suggested that diagnostic CA using iodixanol, an iso-osmolar contrast media, leads significant impairment in respiratory functions. Due to the persistence of these reductions even 2 hours after CA, ventilatory functions should be considered especially in patients whose body compositions or hydration levels are not within the desired physiological range.
机译:目的。这项研究的目的是评估碘克沙醇(一种等渗性造影剂)对肺功能的急性影响,并评估身体成分,以发现其在引起这种恶化中的作用。方法。该研究纳入了接受诊断性冠状动脉造影(CA)的35例男性和25例女性患者。在进行CA之前,通过测量患者的体重指数(BMI)和腰臀比(WHR)来评估所有患者的身体成分。通过生物阻抗分析测量了人体总水(TBWs),脂肪量(FMs),无脂肪量(FFM)和基础代谢率(BMR)。在每位患者中使用碘克沙醇通过radial动脉途径进行CA。这些患者的肺功能测试在CA之前,期间和之后2小时进行。 FEV1?,FEF25–75%?和FVC?通过从CA之后的测量中减去测量的基准值来计算参数。结果。血管造影术导致强制呼气量在1?sec内显着降低(FEV1,从94.17?±?18.83降至84.45?±?18.31,),强制肺活量(FVC,从96.57?±?15.82降至88.31?±?17.96,) ,并且强制呼气流量在25%至75%之间(FEF25%至75%从82.54?±?24.26到72.11?±?25.41,),并且在男性患者CA后2小时后仍然较低。 FEV1值为103.40±17.79〜94.96±17.063()。 FVC值为107.20±±19.03〜99.08±±20.56()。女性患者CA前后,FEF25-75%的值分别为83.92?±?24.30至73.24?±?20.45(),在CA后2?h后仍较低。 FEV1 / FVC比率保持不变。 FEF25–75%?与FFM,TBW和WHR(;和and分别)和FVC在统计上相关吗?与男性患者的WHR相关(,)。结论。我们的数据表明,使用碘克沙醇(一种等渗的造影剂)诊断CA会导致呼吸功能严重受损。由于这些减少甚至在CA后2小时仍持续存在,因此,尤其是对于身体成分或水合水平不在所需生理范围内的患者,应考虑通气功能。

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