The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance

摘要

Background Previous studies have demonstrated that postprandial hyperglycemia attenuates brachial artery flow-mediated dilation (FMD) in prediabetic patients, in diabetic patients, and even in normal subjects. We have previously reported that postprandial hyperinsulinemia also attenuates FMD. In the present study we evaluated the relationship between different degrees of postprandial attenuation of FMD induced by postprandial hyperglycemia and hyperinsulinemia and differences in ingested carbohydrate content in non-diabetic individuals. Methods Thirty-seven healthy subjects with no family history of diabetes were divided into 3 groups: a 75-g oral glucose loading group (OG group) (n =?14), a test meal group (TM group) (n?=?12; 400?kcal, carbohydrate content 40.7?g), and a control group (n?=?11). The FMD was measured at preload (FMD0) and at 60?minutes (FMD60) and 120 (FMD120) minutes after loading. Plasma glucose (PG) and immunoreactive insulin (IRI) levels were determined at preload (PG0, IRI0) and at 30 (PG30, IRI30), 60 (PG60, IRI60), and 120 (PG120, IRI120) minutes after loading. Result Percentage decreases from FMD0 to FMD60 were significantly greater in the TM group (?21.19%?±?17.90%; P? Conclusion Differences in the attenuation of postprandial FMD induced by different postprandial insulin levels may occur a long time postprandially but not shortly after a meal.