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>Metastatic Carcinoma Occurring in a Gastric Hyperplastic Polyp Mimicking Primary Gastric Cancer: The First Reported Case
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Metastatic Carcinoma Occurring in a Gastric Hyperplastic Polyp Mimicking Primary Gastric Cancer: The First Reported Case
Hyperplastic polyps of the stomach are regarded as benign. However, in rare cases they may contain incipient primary carcinomas. To our knowledge, breast carcinoma metastatic to a gastric hyperplastic polyp has not yet been reported. We describe the case of a 69-year-old woman to whom a gastric polyp was endoscopically excised. The patient had previously undergone a right mastectomy for mixed, invasive ductal and lobular carcinoma 5 years earlier. Histological sections from the gastric lesion showed typical features of hyperplastic polyp with foci of poorly differentiated adenocarcinoma including signet ring cells infiltrating the lamina propria. The histologic findings were consistent with a primary gastric cancer. However, the carcinoma cells were immunopositive for estrogen and progesterone receptors and GATA3 and negative for CDX2, Hep Par 1, and MUC5AC. E-cadherin showed membranous reactivity in some of the carcinoma cells while in others it was negative. Accordingly, metastatic mixed, lobular and ductal breast carcinoma was diagnosed. We conclude that metastatic adenocarcinoma mimicking primary gastric cancer can be rarely encountered in hyperplastic gastric polyps.
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机译:胃增生性息肉被认为是良性的。但是,在极少数情况下,它们可能包含初期的原发癌。据我们所知,尚未转移至胃增生性息肉的乳腺癌。我们描述了一个内窥镜切除胃息肉的69岁女性的病例。该患者先前在5年前因混合性浸润性导管和小叶癌接受了右乳房切除术。胃病变的组织学切片显示增生性息肉的典型特征是低分化腺癌,包括浸润固有层的印戒细胞。组织学结果与原发性胃癌一致。但是,癌细胞对雌激素和孕激素受体和GATA3呈免疫阳性,而对CDX2,Hep Par 1和MUC5AC呈阴性。 E-钙粘着蛋白在某些癌细胞中显示出膜反应性,而在另一些则为阴性。因此,诊断出转移性混合性,小叶和导管性乳腺癌。我们得出结论,增生性胃息肉很少会出现模仿原发性胃癌的转移性腺癌。
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