Rhodotorulaspp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. The current study reports a case of onychomycosis caused byRhodotorula glutinisin a 74-year-old immunocompetent female. The causative agent was identified asR. glutinisbased on the pinkish-orange color; mucoid-appearing yeast colonies on Sabouraud Dextrose Agar at 25°C; morphological evaluation in the Corn Meal-Tween 80 agar; observed oval/round budding yeast at 25°C for 72 hours; no observed pseudohyphae; positive urease activity at 25°C for 4 days; and assimilation features detected by API ID 32C kit and automated Vitek Yeast Biochemical Card 2 system. Antifungal susceptibility test results were as follows: amphotericin B (MIC = 0.5 µg/mL), fluconazole (MIC = 128 µg/mL), itraconazole (MIC = 0.125 µg/mL), voriconazole (MIC = 1 µg/mL), posaconazole (MIC = 0.5 µg/mL), anidulafungin (MIC = 0.5 µg/mL), and caspofungin (MIC = 16 µg/mL). Antifungal therapy was initiated with oral itraconazole at a dose of 400 mg/day; seven-day pulse therapy was planned at intervals of three weeks. Clinical recovery was observed in the clinical evaluation of the patient before the start of the third cure. AlthoughR. glutinishas rarely been reported as the causative agent of onychomycosis, it should be considered.
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机译：杜鹃花已成为机会病原体，特别是在免疫功能低下的患者中。目前的研究报道了由74岁的具有免疫能力的女性鼠李糖球菌引起的甲癣。病原被确定为R。面筋基于粉红色-橙色;在25°C时Sabouraud葡萄糖琼脂上出现粘液样的酵母菌落;玉米粉-吐温80琼脂的形态学评估;在25°C下观察到椭圆/圆形发芽酵母72小时;没有观察到假菌丝;在25°C下持续4天的脲酶活度为正; API ID 32C套件和自动Vitek Yeast生化卡2系统检测到的同化和同化特征。抗真菌药敏试验结果如下：两性霉素B（MIC =0.5μg/ mL），氟康唑（MIC =128μg/ mL），伊曲康唑（MIC =0.125μg/ mL），伏立康唑（MIC =1μg/ mL），泊沙康唑（MIC =0.5μg/ mL），阿尼芬净（MIC =0.5μg/ mL）和卡泊芬净（MIC =16μg/ mL）。口服伊曲康唑开始抗真菌治疗，剂量为400μg/天;计划每三周间隔七天脉冲治疗。在第三次治疗开始之前，在对患者的临床评估中观察到临床恢复。虽然R。很少有人报告说臀肌是甲癣的病原体，应该考虑使用。
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