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首页> 外文期刊>Cancer Management and Research >An efficient method that combines the ThinPrep cytologic test with E6/E7 mRNA testing for cervical cancer screening
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An efficient method that combines the ThinPrep cytologic test with E6/E7 mRNA testing for cervical cancer screening

机译:一种结合ThinPrep细胞学检测与E6 / E7 mRNA检测进行宫颈癌筛查的有效方法

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Background: Cervical cancer is strongly associated with persistent human papillomavirus (HPV) infections. The ThinPrep cytologic test (TCT), HPV DNA detection, and E6/E7 mRNA testing are widely used to screen for cervical abnormalities. Purpose: This study aimed to find a suitable method for cervical cancer diagnosis (but not for cervical cancer distant metastasis), especially among women whose TCT results are atypical squamous cells of undetermined significance (ASCUS) or worse (including ASCUS). Patients and methods: A total of 301 samples from Wenzhou People’s Hospital from June 2014 to September 2017 were collected, we conducted comparative analysis of the diagnostic performance of several conventional screening methods both individually and in combination. Results: We compared the sensitivity, specificity, positive predictive value, negative predictive value, and Youden index retrospectively estimated not only by single TCT, HPV DNA detection, or E6/E7 mRNA testing but also by combination methods, such as TCT+HPV DNA, TCT+E6/E7 mRNA, or TCT+HPV DNA+E6/E7 mRNA. Screening under TCT+E6/E7mRNA was confirmed with relatively higher sensitivity of 76.1% (95% CI: 0.659–0.841), specificity of 74.6% (95% CI: 0.681–0.803), and the highest Youden index of 0.507. Conclusion: The joint screening methods showed relatively reliable specificity and sensitivity for cervical disease screening, and detection by TCT+E6/E7 mRNA has the potential to be a widely used clinical method for cervical cancer screening.
机译:背景:宫颈癌与持续性人乳头瘤病毒(HPV)感染密切相关。 ThinPrep细胞学检测(TCT),HPV DNA检测和E6 / E7 mRNA检测被广泛用于筛查宫颈异常。目的:本研究旨在寻找一种适用于子宫颈癌诊断的方法(但不适用于子宫颈癌的远处转移),尤其是在那些其TCT结果为具有不确定意义的非典型鳞状细胞(ASCUS)或更严重的女性(包括ASCUS)的女性中。患者和方法:2014年6月至2017年9月,共收集了301例温州人民医院的样本,我们对几种常规筛查方法的诊断性能进行了比较分析,无论是单独方法还是联合方法。结果:我们比较了不仅通过单次TCT,HPV DNA检测或E6 / E7 mRNA测试,还通过TCT + HPV DNA等组合方法回顾性评估的敏感性,特异性,阳性预测值,阴性预测值和Youden指数,TCT + E6 / E7 mRNA或TCT + HPV DNA + E6 / E7 mRNA。证实在TCT + E6 / E7mRNA下进行筛选具有相对较高的灵敏度,灵敏度为76.1%(95%CI:0.659-0.841),特异性为74.6%(95%CI:0.681-0.803),最高的尤登指数为0.507。结论:联合筛查方法对宫颈疾病的筛查具有相对可靠的特异性和敏感性,而TCT + E6 / E7 mRNA的检测有望成为宫颈癌筛查的一种广泛应用的临床方法。

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