Correlation between Intratumor Microvessel Density and Ki-67 Malignancy Marker in Bitch Mammary Cancer

摘要

The goal of the study is to evaluate and to correlate the significance of intratumor microvessel density with tumor malignancy degree. Tumor malignancy was appreciated using proliferating markers such as Ki-67, histology index, mitotic index, tumor size, and histology type. The study was realized using different histology types of bitch mammary tumors according to WHO classifications. Our results indicate a direct correlation between intratumor microvessel densities and mentioned proliferating marker, respectively Ki-67. The study of angiogenic profile of mammary tumors delivers enough dates about them, but intratumor microvessel density should be associated with reliable parameters that indicate correctly mammary tumor malignancy. Our dates obtained by Ki-67 marker quantification correlated with malignancy histological grade in studied canine mammary tumors confirming its utility in bitch mammary cancer