Invivo and Invitro Comparative Results for the Hypolipemic Effect of Aminated Dextran Polymers

摘要

The present paper reports on the derivatization of a polysaccharide (dextran), along with the bile acid binding capacities (invitro) and plasma lipid level lowering capacities (invivo) of the products. The A and B compounds were compared to a commercially hypolipidemic drug, Cholestyramin, with the following results:in vitro study of the values of the binding constants determined for sodium cholate (NaCA) showes that physico-chemical properties of these polymers can influence their binding capacity in the following manner: B A Cholestyramin. in vivo results differ from the in vitro data, which demonstrate the following order of binding efficiencies: Cholestyramin BA. The differences in the efficiency order for the binding of bile acids and the lowering of plasma lipid levels may be due to environmental variations in the digestive tract (pH, electrolytes, fatty acids). Aminated polysaccharides administered in rats did not affect the digestive system, liver or pancreas functions.