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Configurational forces for growth and shape regulations in morphogenesis

机译:形态发生中生长和形状调节的构型力

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Morphogenetic theories investigate the mechanisms of creation and regulation of definite biological forms in living organisms. The incredible diversity of shapes and sizes is generated through a barely unknown coordination of biochemical processes occurring at molecular levels. Such a crosstalk not only defines the rules of a robust scheme of matter differentiation, but it also has the capacity to adapt with respect to some variations of the environmental conditions. In this work, we propose a continuum model of growth and mass transport for biological materials during morphogenetic processes. Using the theory of configurational forces, we define the thermomechanical bases for understanding how both the mechanical and the biochemical states can orchestrate growth. The model is successfully applied to describe the morphogen-driven growth control in the imaginal wing disc of Drosophila melanogaster.
机译:形态发生理论研究了活生物体中确定的生物形式的产生和调控机制。形状和大小的惊人多样性是通过在分子水平发生的生化过程的几乎未知的协调而产生的。这种串扰不仅定义了一种可靠的物质区分方案的规则,而且还具有适应环境条件某些变化的能力。在这项工作中,我们提出了形态发生过程中生物材料生长和物质运输的连续模型。使用构型力理论,我们定义了热机械基础,以了解机械状态和生化状态如何协调增长。该模型已成功应用于描述果蝇果蝇翼盘中由形态发生子驱动的生长控制。

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