Expression of 2-nd Receptor of Tumor Necrosis Factor Cytokine (TNFR-II) in Canine Mammary Neoplasms

摘要

Actual study proposes an actual and controversial theme in oncology, such asexpression and distribution of TNF cytokine 2-nd receptor in canine mammary cancer, and itsinvolvement in cancer progression and prognosis. TNFR-II was evaluated by LSABimmunohistochemistry technique using anti-TNFR-II marker. Tumor malignancy was appreciatedusing histology grading (I to III), mitotic index, nuclear grade, tumor size, and histology type. In thestudy were elected benign and malign canine mammary tumors. Distribution and localization ofTNFR-II was restricted in both inflammatory cells from the sustaining stroma of studied tumors(macrophage, lymphocyte), and in cancerous epithelial or myoepithelial cells. Obtained datesdemonstrate a direct relation between histologic grade and TNFR-II expression; TNFR-II had a lowerexpression in benign and differentiated grade I canine mammary tumors (cancerous epithelial andmyoepithelial cells), and a higher expression in poorly differentiated ones (grade II cancers).