Cases with Hyperplasia and Neoplasia in Endocrine Glands in Dogs

摘要

Endocrine tumors are found sporadically in both humans and animals. They originate from endocrine organs and diffuse neuroendocrine system. Our paper presents cases with tumors/hyperplasia in various endocrine glands in dogs that were diagnosed in the Department of Pathology (FMV Cluj-Napoca, Romania). The material was represented by canine bodies and tumors brought to perform the necropsy and histopathological assessment. Such fragments were collected and fixed in 10% buffered formalin and undergo processing using the regular paraffin technique. In all cases the canine endocrine tumors were diagnosed only after necropsy. In investigated cases were identified simple endocrine neoplasms and some with multiple endocrine tumors. Testicular sertolinomas and/or leydigomas can be considered endocrine tumors since (in some cases) the clinical manifestations are relatively sharp. In one case bearing sertolinoma we observed the feminization syndrome. The adrenal adenoma was diagnosed in a dog whereas another dog had an adrenal gland carcinoma. In one dog we diagnosed a benign pheochromocytoma. Thyroidal tumors were either with the proliferation of follicular cells or with the involvement of parafollicular cells. In one dog showing a thyroidal tumor, a double hyperplasia of the parathyroid glands was diagnosed. The former dog had multiple endocrine tumors aspect known as the Multiple Endocrine Neoplasia (MEN) syndrome. A similar problem occurred in two other subjects who had MEN-like syndromes with testicular and adrenal location. This is the first description of this syndrome in dogs in our country. Endocrine tumors are extremely rare in animals. In dogs suspect to bear endocrine tumors, it is essential to investigate all endocrine glands to determine if the subject presents or not MEN or MEN-like syndrome.