Biocompatibility Study Concerning Hematological Reactions Accompanying Subcutaneous Implantation of Some Dental Products in

摘要

The experiment aims to evaluate, by a hematological point of view, theconsequences (biocompatibility) of subcutaneous implantation of some dental composites (Ivoclar,Noritake, Vita, Vitadur) special prepared for this purpose, on blood cells (RBC, WBC and PLT). Theexperiment was conducted on 45 healthy Wistar adult rats, randomly and equally distributed in 9groups of 5 animals per group. The implantation of dental composites was made subcutaneously, inthe dorso-thoracic region of the rats. Subsequently, the rats were observed during the experiment (10weeks) for any clinical (local or general), pathological and hematological reactions. The resultsobtained did not show any clinical or pathological effects, neither locally or even less systemic. As forhematological parameters investigated, the values obtained in experimental groups comparatively withthe reference one did not show, with a very few exceptions, statistically significant differences, whichindicate a possible pathogen effect of the studied dental composites on the bone marrow hematopoieticcenters, or on the cellular components of blood, whether its red, white blood cells or platelets.