Preparation of manganese-based perovskite nanoparticles using a reverse microemulsion method: biomedical applications

摘要

In this study, La$_{0.7}Sr$_{0.3}Mn$_{0.98}$Ti$_{0.02}$O$_{3}$ (LSMTO) nanoparticles with a perovskite structure and an average particle size of 23.5 nm were synthesized using a reverse microemulsion method. In this method, cetyltrimethylammonium bromide (CTAB) was used as a surfactant, 1-butanol as a co-surfactant, $n$-hexane as a continuous oil phase, and an aqueous solution containing metal cations or precipitating agent as a dispersed aqueousphase. The aqueous nanodroplets of microemulsions were used for the formation of perovskite precursor. The obtained precursor was then calcined at 700$^{circ}$C for 4 h to convert the precursor to the perovskite phase. In addition, the heating ability of the LSMTO nanoparticles was evaluated under a safe alternating magnetic field used in magnetic hyperthermia therapy. The results showed the fast magneto-temperature response of the prepared samplewith sufficient heat loss at the therapeutic temperature range, indicating the LSMTO nanoparticles can be used as a self-regulated heating agent in the magnetic hyperthermia therapy.