Genomic profile of a squamous cell carcinoma ex pleomorphic adenoma compared to a head and neck squamous cell carcinoma ☆

摘要

Squamous cell carcinoma (SCC) is the most frequent neoplasm in the head and neck and in oral sites. Head andneck squamous cell carcinoma (HNSCC) is the sixth mostcommon solid cancer, affecting more than 900,000 people worldwide each year. Oral squamous cell carcinoma(OSCC) is the largest subgroup of HNSCC and causes 7400deaths in the United States every year.1 Because of thehigh prevalence and aggressiveness, HNSCC has been studiedby several molecular and cytogenetic techniques. Frequentchromosomal imbalances reported in HNSCC are 3p, 4, 5q,8p, 9p, 11, 13q, and 18q (losses) and 3q25---26, 5p, 8q24,9q22---34, 11q13, 14q24, 16p, 19p, 20q24, and 22q (gains).1The carcinomatous component of carcinoma ex pleomorphic adenoma (CXPA) encompasses a variety of histologicaltumor types, such as adenocarcinoma, myoepithelial carcinoma, epithelial---myoepithelial carcinoma, sarcomatoidcarcinoma, and salivary duct carcinoma.2 Many epidemiological studies about incidence of CXPA showed few or nocases with an SCC component.Despite reports of numerous chromosomal alterations inSCC from other sites, no particular chromosomal imbalanceshave been described for squamous cell carcinoma ex pleomorphic adenoma (SCC-CXPA). The aim of this study wasto identify chromosomal changes associated with SCC-CXPA,comparing with HNSCC data from the literature.