EXPERIMENTAL OSTEOARTHRITIS MODELS IN VETERINARY MEDICINE – RELEVANCE, POTENTIAL AND CHALLENGES

摘要

The aim of the present review is to summarise, classify and outline the benefits and disadvantages of the models for reproducing osteoarthritis, most commonly used in experimental veterinary orthopaedics (spontaneous, chemical and physical). The potential for application of a given experimental model is related to its specific research target – evaluation of pain, role of inflammation, sex, age, motility and overweight, as well as provision of a solid background for testing of modern pharmacological and physical means of disease control. With this regard, the experimental reproduction of osteoarthritis does not focus on model unification, but is a scientific and practical field developing towards broadening and revealing new heuristic and clinical diagnostic horizons related to improving the quality of life in both human and animal patients with osteoarthritis.