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Anxiety and its predictive value for pain and regular analgesic intake after lumbar disc surgery - a prospective observational longitudinal study

机译:腰椎间盘手术后疼痛和定期镇痛药摄入的焦虑及其预测价值-前瞻性观察性纵向研究

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Ongoing pain after surgery is a major problem and influences recovery and the quality of life of the patient. Associations between anxiety and their impact on postoperative pain after herniated disc surgery have been reported, but the results are inconsistent. The aim of the present longitudinal study was to evaluate the predictive value of preoperative anxiety for postoperative ongoing pain and prolonged analgesic intake after herniated disc surgery. 106 patients with lumbar disc herniation were evaluated in the study. Anxiety was measured with the Generalized Anxiety Disorder 7-Item Scale (GAD-7) before surgery. Pain intensity was assessed on a numeric rating scale (NRS) at baseline, 6-weeks and 6-months after surgery. Regression analysis was performed to identify independent predictors of pain and regular utilization of analgesics up to 6?months after surgery while controlling for confounding variables. 42.5% of the patients were rated as anxiety cases (sum scores GAD-7?>?5), mean scores of anxiety showed mild to moderate symptom severity, and 43% suffered from chronic pain before surgery. Six months after surgery, 55.6% of the patients indicated pain levels of 4/10 (NRS) or higher and about 40% still took pain medication on a regular basis, regardless of their preoperative classification as anxiety-case (37.7% and 41.5%). The preoperative pain level was statistically significant for ongoing postsurgical pain in all four analyses (p?
机译:手术后持续的疼痛是一个主要问题,并影响患者的康复和生活质量。据报道,焦虑症与椎间盘突出症对术后疼痛的影响之间存在相关性,但结果不一致。本纵向研究的目的是评估椎间盘突出症术后术前焦虑对术后持续疼痛和延长镇痛药物摄入量的预测价值。本研究评估了106例腰椎间盘突出症患者。术前用广义焦虑症7项量表(GAD-7)测量焦虑。在基线,手术后6周和6个月以数字评分量表(NRS)评估疼痛强度。在控制混杂变量的同时,进行回归分析以识别疼痛的独立预测因子以及术后长达6个月的止痛药的常规使用情况。 42.5%的患者被评定为焦虑症患者(总分GAD-7≥5),平均焦虑评分显示轻度至中度症状严重程度,而43%的患者在手术前患有慢性疼痛。手术六个月后,有55.6%的患者表示疼痛水平为4/10(NRS)或更高,并且约40%的患者仍定期服用止痛药,而不论术前的焦虑情况如何(37.7%和41.5%) )。在所有四个分析中,术前疼痛水平对于进行中的术后疼痛均具有统计学意义(p <0.001)。通过二元logistic回归分析,术前疼痛强度,但人口统计学因素和术前焦虑均未被确定为术后疼痛和腰椎间盘手术长达6个月的镇痛药物的预测指标。我们没有发现任何证据表明椎间盘手术前存在焦虑是持续疼痛和术后定期服用镇痛药的预后因素。腰椎间盘手术后直至6个月,仅术前疼痛强度可预示疼痛加剧和继续需要镇痛药。 Clinicaltrials.gov NCT01488617。 2011年12月6日注册。

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