Although adrenocorticotropic hormone is generally considered to play a major role in the regulation of adrenal glucocorticoid secretion, several reports have suggested that other pituitary hormones (e.g., prolactin) also play a significant role in the regulation of adrenal function. The aim of the present study was to measure the adrenocortical cell area and to determine the effects of the transition from the prepubertal to the postpubertal period on the hyperprolactinemic state induced by domperidone (4.0 mg kg-1 day-1, sc). In hyperprolactinemic adult and young rats, the adrenals were heavier, as determined at necropsy, than in the respective controls: adults (30 days: 0.16 ± 0.008 and 0.11 ± 0.007; 46 days: 0.17 ± 0.006 and 0.12 ± 0.008, and 61 days: 0.17 ± 0.008 and 0.10 ± 0.004 mg for treated and control animals, respectively; P
展开▼
机译：尽管通常认为促肾上腺皮质激素在调节肾上腺糖皮质激素的分泌中起主要作用，但一些报告表明，其他垂体激素（例如催乳激素）也在调节肾上腺功能中起重要作用。本研究的目的是测量肾上腺皮质细胞面积，并确定从青春期前到青春期后过渡期对多潘立酮（4.0 mg kg-1 day-1，sc）诱发的催乳激素过多状态的影响。剖检时，在高泌乳素成年和成年大鼠中，肾上腺比相应对照组重：成年（30天：0.16±0.008和0.11±0.007; 46天：0.17±0.006和0.12±0.008和61天：治疗动物和对照动物分别为0.17±0.008和0.10±0.004 mg; P
展开▼
