Immunohistochemical Expression of Tissue Inhibitor of Metalloproteinase-1 (Timp-1) in Invasive Breast Carcinoma

摘要

Tissue inhibitor of metalloproteinase-. (TIMP-.) is a natural inhibitor of matrix metalloproteinases (MMPs). Aim of this study was to assess the immunohistochemical expression of TIMP-. in invasive breast carcinomas, and to examine its association with classical clinico-pathological parameters, oestrogen receptor, progesterone receptor and Her-.eu protein expression. Immunohistochemistry was used to determine the expression of TIMP-. on .. paraffi n-embedded breast tissue specimens - .. with invasive ductal carcinoma, .. with invasive lobular carcinoma, and .. specimens from patients with fi brocystic breast disease. TIMP-. protein was immunodetected in the carcinoma cells, fi broblasts and infl ammatory cells of the stroma in ..,.., ..,.., and ..,.. of cases, respectively. TIMP-. protein expression in carcinoma cells showed positive correlation with TIMP-. protein expression in peritumoural fi broblasts (p=.,...). Positive peritumoural fi - broblast TIMP-. expression was associated with histological tumour type with higher frequency in ductal carcinomas (p=.,...). Negative association was found between TIMP-. protein expression in carcinoma cells and HER-.eu nuclear staining (p=.,...). TIMP-. may be particularly useful as a predictive marker in breast carcinoma when evaluated along with HER-.eu protein being a promising indicator of favourable prognosis in breast carcinoma.ate tha