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Gene-specific selective sweeps in bacteria and archaea caused by negative frequency-dependent selection

机译:负频率依赖性选择导致细菌和古细菌的基因特异性选择性扫描

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Background Fixation of beneficial genes in bacteria and archaea (collectively, prokaryotes) is often believed to erase pre-existing genomic diversity through the hitchhiking effect, a phenomenon known as genome-wide selective sweep. Recent studies, however, indicate that beneficial genes spread through a prokaryotic population via recombination without causing genome-wide selective sweeps. These gene-specific selective sweeps seem to be at odds with the existing estimates of recombination rates in prokaryotes, which appear far too low to explain such phenomena.
机译:背景细菌和古细菌(统称原核生物)中有益基因的固定通常被认为通过搭便车效应消除了先前存在的基因组多样性,这种现象被称为全基因组选择性扫描。然而,最近的研究表明,有益基因通过重组传播通过原核种群,而不会引起全基因组选择性扫描。这些基因特异性的选择性扫描似乎与原核生物中重组率的现有估计不一致,后者似乎太低而无法解释这种现象。

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