Epidemiological aspects of rotavirus and adenovirus in hospitalized children with diarrhea: a 5-year survey in Beijing

摘要

Background Diarrhea caused by viruses is a global problem among young children. We investigated two of the most important agents, rotavirus and adenovirus, to provide epidemiological evidence for a better understanding of their role among children with acute diarrhea. Methods A total of 3147 hospitalized children were enrolled in the study during 2010?~?2014. Antigen testing for rotavirus and DNA testing for adenovirus were performed on stool specimens collected from participants. Results There were 1985 cases of community-acquired diarrhea (CAD) and 1162 cases of hospital-acquired diarrhea (HAD). A total of 692 cases (22.0?%) were positive for rotavirus. Rotavirus was detected in more children with HAD than in those with CAD (24.6?%; 286/1162 vs. 20.5?%; 406/1985). A total of 324 cases (10.3?%) were adenovirus positive. There was a significant difference between the CAD group and HAD group (9.5?%; 188/1985 vs. 11.7?%; 136/1162: χ 2?=?3.957, p =?0.047). Co-infection was found in only 35 children (1.11?%), and the co-infection rate was similar between the CAD and HAD groups ( χ 2?=?1.174, p =?0.279). There was no association between sex and the detection rate of these viruses. The positive rate was significantly different for rotavirus among CAD cases ( χ 2?=?27.979, p 2?=?34.362, p Conclusion Detection rates for rotavirus and adenovirus were significantly higher in children with HAD than those with CAD, but co-infection was very low. A high prevalence of rotavirus was identified in neonates with diarrhea. Vaccination for rotavirus gastroenteritis should be considered in neonates.