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Reporting of measures of accuracy in systematic reviews of diagnostic literature

机译:报告诊断性文献系统评价的准确性

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Background There are a variety of ways in which accuracy of clinical tests can be summarised in systematic reviews. Variation in reporting of summary measures has only been assessed in a small survey restricted to meta-analyses of screening studies found in a single database. Therefore, we performed this study to assess the measures of accuracy used for reporting results of primary studies as well as their meta-analysis in systematic reviews of test accuracy studies. Methods Relevant reviews on test accuracy were selected from the Database of Abstracts of Reviews of Effectiveness (1994–2000), which electronically searches seven bibliographic databases and manually searches key resources. The structured abstracts of these reviews were screened and information on accuracy measures was extracted from the full texts of 90 relevant reviews, 60 of which used meta-analysis. Results Sensitivity or specificity was used for reporting the results of primary studies in 65/90 (72%) reviews, predictive values in 26/90 (28%), and likelihood ratios in 20/90 (22%). For meta-analysis, pooled sensitivity or specificity was used in 35/60 (58%) reviews, pooled predictive values in 11/60 (18%), pooled likelihood ratios in 13/60 (22%), and pooled diagnostic odds ratio in 5/60 (8%). Summary ROC was used in 44/60 (73%) of the meta-analyses. There were no significant differences in measures of test accuracy among reviews published earlier (1994–97) and those published later (1998–2000). Conclusions There is considerable variation in ways of reporting and summarising results of test accuracy studies in systematic reviews. There is a need for consensus about the best ways of reporting results of test accuracy studies in reviews.
机译:背景技术有多种方法可以在系统评价中总结临床测试的准确性。仅在一次小型调查中评估了汇总指标报告的差异,该调查仅限于在单个数据库中发现的筛查研究的荟萃分析。因此,我们进行了这项研究,以评估用于报告基础研究结果的准确性的度量,以及它们在测试准确性研究的系统评价中的荟萃分析。方法从1994-2000年有效性评论摘要数据库中选择有关测试准确性的评论,该数据库以电子方式搜索七个书目数据库并手动搜索关键资源。筛选了这些评论的结构化摘要,并从90篇相关评论的全文中提取了有关准确性测度的信息,其中60篇进行了荟萃分析。结果敏感性或特异性用于报告65/90(72%)综述中的初次研究结果,26/90(28%)的预测值和20/90(22%)的似然比。对于荟萃分析,在35/60(58%)的评论中使用了合并的敏感性或特异性,在11/60(18%)中使用了合并预测值,在13/60(22%)中使用了合并似然比,并在诊断中比较了比值在5/60(8%)。总结在44/60(73%)的荟萃分析中使用了ROC。在较早发表的评论(1994-97年)和较晚发表的评论(1998-2000年)之间,测试准确性的度量没有显着差异。结论在系统评价中报告和总结测试准确性研究结果的方式存在很大差异。对于在审查中报告测试准确性研究结果的最佳方法,需要达成共识。

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