Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity

Yinong Huang; Yanling Zhang; Bing Zhao; Qiping Xu; Xiushi Zhou; Houyan Song; Min Yu; Wei Mo

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Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity

机译：RGD-hirudin与凝血酶结合的结构基础：Tyr3和五个C末端残基对于抑制凝血酶活性至关重要

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《BMC Structural Biology》 |2014年第1期|共页
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Yinong Huang; Yanling Zhang; Bing Zhao; Qiping Xu; Xiushi Zhou; Houyan Song; Min Yu; Wei Mo;
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1. Kinetics of Activated Thrombin-activatable Fibrinolysis Inhibitor (TAFIa)-catalyzed Cleavage of C-terminal Lysine Residues of Fibrin Degradation Products and Removal of Plasminogen-binding Sites [J] . Jonathan Foley, Paul Cook, Michael Nesheim The Journal of biological chemistry . 2011,第22期

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2. Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides [J] . Rathi Saravanan, Daniel A Holdbrook, Jitka Petrlova, Nature Communications . 2018,第1期

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3. Elucidation of the structural basis for the slow reactivity of thrombin with plasminogen activator inhibitor-1 [J] . Rezaie AR. Biochemistry . 1998,第38期

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4. Label Free Proteomics Profiling Unveils Downregulation of Thrombin Mediated Signaling and Aggregation of Human Platelets upon Treatment with Thrombin Inhibitors [C] . Cristina C. Clement, Ebenezer L.V. Ewul, Anna Babinska, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：标记免费蛋白质组学分析揭开凝血酶介导的信号传导和人血小板聚集在用凝血酶抑制剂上进行的下调
5. Structural and thermodymanic studies of the thrombin-binding aptamer and related quadruplexes. [D] . Tang, Chungfei Esther. 2006

机译：凝血酶结合适体和相关四链体的结构和热力学研究。
6. Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity [O] . Yinong Huang, Yanling Zhang, Bing Zhao, 2014

机译：RGD-hirudin与凝血酶结合的结构基础：Tyr3和五个C末端残基对于抑制凝血酶活性至关重要
7. Structural basis of RGD-hirudin binding to thrombin: Tyr and five C-terminal residues are crucial for inhibiting thrombin activity [O] . 2014

机译：RGD-hirudin与凝血酶结合的结构基础：Tyr和五个C末端残基对于抑制凝血酶活性至关重要

Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity

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