What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II ?￠???? information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy

摘要

ABSTRACT The individual variance in the efficiency of repair of damage induced by genotoxic therapies may be an important factor in the assessment of eligibility for different anticancer treatments, the outcomes of various treatments and the therapy-associated complications, including acute and delayed toxicity and acquired drug resistance. The second part of this paper analyses the currently available information about the possibilities of using experimentally obtained knowledge about individual repair capacity for the purposes of personalised medicine and healthcare.