New Gastroprotective Activity of Methanolic Extracts of Hyoscyamus albus (Solanaceae) and Umbilicus rupestris Leaves (Crassulaceae) Against Gastric Mucosal Injury Induced by Ethanol in Rats

摘要

The present study was performed to evaluate the anti-ulcer activity of methanolic extract of Hyoscyamus albus and Umbilicus rupestris against ethanol-induced gastric ulcer. Experimental groups were orally pre-treated with and 100 mg/kg and 200 mg/kg b.w of methanolic extracts HAMeOH and URMeOH. Ulcer control group were pre-treated just with absolute ethanol and reference group was orally pre-treated with omeprazole (20 mg/kg b.w). After one hour of pretreatment, all rats were received the absolute ethanol to generate gastric mucosal injury. And after one hour, our rats were anesthetized and sacrificed and the ulcer areas of the gastric walls were determined. Grossing evaluation has revealed that the negative control rats exhibited severe mucosal injury, whereas, pre-treatment with U. rupestris leaf extract and H. albus has resulted in significantly anti gastric mucosal injury and flattening of the mucosal folds. Histological studies of the gastric wall that the pre-treated with URMeOH and HAMeOH leaf extract was pronounced as gastric protection along followed by reduction or inhibition of leucocytes in the infiltration of the sub-mucosa.