Inactivation of BANK1 in a novel IGH-associated translocation t(4;14)(q24;q32) suggests a tumor suppressor role in B-cell lymphoma

摘要

Immunoglobulin heavy chain ( IGH ) gene-associated translocations occur frequently in different subtypes of B-cell lymphomas. 1 These translocations result in deregulated expression of partner genes and play pivotal roles in the pathogenesis of lymphomas. Molecular characterization of IGH -associated translocation breakpoints has been instrumental in the identification of genes important to the development of normal and malignant B cells.