SWR/J mice are susceptible to alkylator-induced myeloid leukemia

摘要

Therapy-related acute myeloid leukemia (t-AML) is a late complication following chemotherapy and/or radiation therapy. Approximately 10% of AML cases are therapy related and the incidence is rising. 1 Alkylator-associated t-AML has a latency of 5–7 years, is often preceded by a myelodysplastic phase (t-MDS) and is frequently associated with loss of material from chromosomes 5 and/or 7 in humans. 2 , 3 The survival of these patients is poor, motivating efforts to improve treatment and prevention strategies.