P16 Expression Correlation with Clinicopathological Features of Oral Cavity Squamous Cell Carcinoma Patients in Bali

摘要

Background: Oral cavity cancer is considered as a major healthproblem worldwide and has been associated with high recurrence rateand poor prognosis. Oral cavity squamous cell carcinoma (OCSCC) inSanglah General Hospital Denpasar contributed to 71.7% of all headand neck cancer from 2002-2011 with an increasing trend annually.Advances in our understanding of OCSCC have not improved theoutcome in OCSCC management signifcantly. Therefore, many studieshave focused on the roles of biomolecular markers in OCSCC. One ofbiomolecular marker that has been the focus of many OCSCC studiesis p16.Method: This was an analytic cross sectional study with 31 samplesto determine the association of p16 expression with age group, tumorlocation, stage, and grade in OCSCC. Data was analyzed descriptivelyand the association between variables were evaluated with Chi-Squareor Fisher’s Exact Test with a p value <0.05 was considered signifcant.Results: From 31 samples collected, the mean age was 56.19±15.197years old. 17 samples (54.8%) were female and 17 samples (54.8%)were from the ≤60 years old age group. Majority of the tumor waslocated on the tongue (14 samples; 45.2%) with postero-inferior grouplocation (19 samples; 61.3%). Almost half of the samples were in StageIVA-B (15 samples; 48.4%) and within high grade group (24 samples;77.4%) meanwhile 21 samples (67.7%) were in low p16 expressiongroup. There was a signifcant association between p16 expressionwith tumor grade group (p=0,044).Conclusion: p16 expression was signifcantly associated with tumorgrade in OCSCC patients.