Comparison of Endometrial Receptivity Between Agonist and Antagonist Protocol in Mice Uterus

摘要

Background: The implantation rate of IVF remains low due to the adverse effect of ovarian stimulation on endometrial receptivity.? Integrin β3 is the best known marker for endometrial receptivity evaluation. In this study,? the impact of antagonist and agonist protocol on the expression of integrin β_(3? )?during implantation window was investigated. Methods : Two ovarian stimulation protocols were used, involving FSH plus GnRH agonist and FSH plus GnRH antagonist. Uterus sample were collected 48 hr after ovarian stimulation and the expression of integrin β_(3 )detected by immunohistochemistry. Results: The GnRH antagonist treated mice showed significantly lower integrin β_(3 )expression in endometrium during window of implantation than GnRH agonist treated mice. Conclusions : Antagonist protocol has more adverse impact on endometrial receptivity of mice uterus than agonist protocol.