Deng and Lynch (1, 2) proposed to characterize deleterious genomic mutations from changes in the mean and genetic variance of fitness traits upon selfing in outcrossing populations. Such observations can be readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. A significant inbreeding depression and an increase of genetic variance for all traits analyzed were observed. Deng and Lynch’s (2) procedures were employed to estimate the genomic mutation rate (U), mean dominance coefficient (left( {ar h} ight)) , mean selection coefficient (left( {ar s} ight)) , and scaled genomic mutational variance ( V m/Ve). On average, ? , (left( {hat ar h} ight)) , (left( {hat ar s} ight)) and (rac{{hat V_m }}{{V_e }}) (^ indicates an estimate) are 0.84, 0.30, 0.14 and 4.6E-4 respectively. For the true values, the ? and (hat ar h) are lower bounds, and (hat ar s) and (rac{{hat V_m }}{{V_e }}) upper bounds.
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机译：Deng和Lynch（1，2）提出了根据异性群体自交后适应性状特征的均值和遗传方差的变化来表征有害基因组突变的特征。这样的观察很容易在周期性孤雌激素中获得。对两个这样的水蚤种群进行了自拍照和生命表实验。观察到显着的近交抑郁和所有分析特征的遗传变异增加。使用Deng和Lynch（2）的过程来估计基因组突变率（U），平均优势系数（ left（{ bar h} right）），平均选择系数（ left（{ bar s } right）），然后按比例缩放基因组突变方差（V m / V e ）。一般， ？ ，（ left（{ hat bar h} right）），（ left（{ hat bar s} right））和（ frac {{ hat V_m}}} {{ V_e}} ）（^表示估算值）分别为0.84、0.30、0.14和4.6E-4。对于真实值，？和（ hat bar h ）是下界，（ hat bar s ）和（ frac {{ hat V_m}} {{V_e}} ）是上限。
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