Heparin-like polyelectrolyte multilayer coatings based on fungal sulfated chitosan decrease platelet adhesion due to the increased hydration and reduced stiffness

摘要

The aim of this research was to develop antithrombotic polyelectrolyte multilayer nanocoatings that can decrease platelet adhesion to surfaces of blood contacting implants and devices and prevent thrombus formation. It has been shown that developed in this study sulfated derivatives of highly pure fungal chitosan fabricated under controlled conditions can be more effective in the decrease of platelet adhesion compared with heparin when they are used as polyanions in polyelectrolyte multilayer coatings. The application of novel coatings based on sulfated fungal chitosan in stents and other blood contacting devices can essentially improve blood compatibility and safety of the use of implants and decrease the probability of medical complications. The stiffness of nanocoatings depends on their hydration degree and plays important role in prevention of protein adsorption and platelet adhesion.