The Efficiency of Garlic Extract in Prevention of Lead Acetate Toxicity on Fallopian Tube - A Hormonal Study

摘要

(i) Objective: This study was conducted to analyze the effect of lead acetate on the serum estrogen andprogesterone levels in adult mice and the role of garlic extract. (ii) Study Design: Laboratory based RandomizedControl Trial. (iii) Place and duration of study: Anatomy Department, Army Medical College, Rawalpindi incollaboration with National Institute of health from April-June 2013. (iv) Material and Methods: In this study 30female BALBc mice were selected and randomly divided into three groups.10 animals were placed in each group.Group A being the control received only the laboratory diet prepared at NIH. Group B was given lead acetate at adose of 30 mg/kg/day. Group C was given lead acetate 30 mg/kg/day and garlic extract 500 mg/kg/day through oralgavage tube for 60 days. The mice were sacrificed and dissected at the end of 60 days. Using intracardiac route 5mlblood was taken from each animal for hormonal assay. (v) Results: Hormone assay of the serum in theexperimental group B showed decrease in serum estrogen and progesterone levels as compared to the group A andthere was minor decrease in the hormonal levels in group C. (vi) Conclusion: Lead acetate causes decrease in theserum estrogen and progesterone levels in adult female mice and garlic extract prevents this effect.