Introduction to the BioTM special issue “Nucleic Acid Delivery: Enabling the Drugs of Tomorrow”

摘要

It is my pleasure to introduce the second issue of Bioengineering and Translational Medicine during its inaugural year. This issue focuses on one of the most pressing questions for drug delivery scientists today: How can we engineer systems that protect the sensitive cargo that is DNA and RNA while simultaneously facilitating intracellular delivery? With continuous advances in our understanding of the biology of nucleic acids and their role in a myriad of diseases, it is becoming increasingly evident that nucleic acid therapeutics will be a crux of the personalized medicines of tomorrow. However, we as a society will not be able to capitalize on their promise until we've developed methods for safe and effective delivery.